Isibalo sabantu abacindezelwe amasosha omzimba “singase” sidinge isikhuthazi somuthi wokugomela i-COVID-19

I-webinar ye-Curtis J. Isiguli: Umuthi wokugomela i-COVID-19 nokwelashwa. Isikhulumi: I-Rheumatism Research Foundation. Meyi 11, 2021 (I-Virtual Q&A).
I-webinar ye-Curtis J. Isiguli: Umuthi wokugomela i-COVID-19 nokwelashwa. Isikhulumi: I-Rheumatism Research Foundation. Meyi 11, 2021 (I-Virtual Q&A).
UJeffrey R. Curtis, MD, usihlalo we-COVID-19 Vaccine Clinical Guidance Working Group ye-American Academy of Rheumatology, uthe iziguli ezingenawo amandla omzimba “kungenzeka” zidinga ukusebenzisa ama-booster wokugomela i-COVID-19 esikhathini esizayo.
UCurtis, udokotela wezifo zamathambo, udokotela wezifo eziwumshayabhuqe, kanye noprofesa wezokwelapha eNyuvesi yase-Alabama eBirmingham, utshele abebehambele umcimbi wakamuva we-Q&A obubanjwe yiRheumatology Research Foundation ukuthi ukholelwa ukuthi isikhuthazi sokugomela i-COVID-19 singaba yinto evamile kulezi ziguli.
“Yebo, kunesayensi eminingi, futhi isayensi ithuthuka njalo. Noma ngabe yini ocabanga ukuthi uyazi kule nyanga, ngenyanga ezayo ingahle yehluke, ngakho-ke, ngenxa yalesi sizathu, ngicabanga ukuthi konke esikushoyo noma esikhuluma ngakho kusihlwa Kungashintsha, ”kusho uCurtis etshela abebehambele lesi sithangami. “Mina ngokwami ​​ngicabanga ukuthi abantu bangadinga ama-booster. Kungase kungabi njalo kuwo wonke umuntu, kodwa ngicabanga ukuthi kungase kube yinto evamile ukuthola i-booster bese ukwenze ngezikhathi ezithile. Kungase kugcine kufana nokugomela umkhuhlane, uma kungenjalo minyaka yonke, Bese uwudinga okungenani minyaka yonke.”
Ubuye wengeza ngokuthi kuye ngokwelashwa isiguli esikutholayo, abantu ngabanye bangase bahlomule ekugomeni i-booster noma uchungechunge oluphindaphindiwe lwemigomo.
"Othile engxoxweni uphakamise isimo ukuthi akuwona umthamo noma umuthi abawufunayo, ngakho-ke kuye ngokwelashwa okutholayo, lokhu kuyinto okufanele uxoxe ngayo nomhlinzeki wakho wezempilo," kusho uCurtis. "Kodwa ngicabanga ukuthi umqondo wama-booster kungenzeka ukhange."
Lapho ebuzwa ngamathemba okusebenzisa uchungechunge lokugoma i-Pfizer noma iModerna nesithuthukisi senye inkampani, uCurtis uphendule wathi unethemba lokuthi ochwepheshe bazoncoma ukuthi abantu baqhubeke nokusebenzisa lo mgomo njengomgomo wokuqala.
Uthe: “Kungenzeka ukuthi lokhu ngeke kube wucwaningo olunzulu maduze nje.” “Ngigcwele izinto engizilindele. Kufanele ubambelele ekwesekeni enakuthola kwasekuqaleni.”
UCurtis uphinde waphawula ngemithi ethile ye-rheumatic, okuhlanganisa i-rituximab (Rituxan, Genentech) kanye ne-mycophenolate mofetil, engase yehlise ukusebenza komgomo we-COVID-19.
Uthe: "Ngicabanga ukuthi i-Rituximab izoba ngesinye sezidakamizwa ezithakazelisa kakhulu." I-Rituximab iphumelela kakhulu ekuqedeni ama-B cell futhi yenza kube nzima ngomzimba ukukhiqiza amasosha omzimba. Lokhu kuyinto enhle uma welapha okuthile ngamasosha omzimba ofuna ukuwaqeda, kodwa uma ufuna ukusiza amasosha omzimba ukulwa nezifo esikhathini esizayo, kungase kungabi into enhle. ”
I-Rituximab inganciphisa ukuphendula komzimba ngezinga elikhulu kunezinye izindlela eziningi zokwelapha. I-Mycophenolate mofetil ingenye. "Lezi yizinto ezimbili engingahle ngingabaza kakhulu, ukuqiniseka ngokuphelele ukuthi othile uvikeleke kahle ku-COVID-19."
NgokukaCurtis, izinkinga ezihlanganisa i-JAK inhibitors kanye nokuncishiswa kokusabela kokugoma, okuhlanganisa ne-ACR COVID-19 Vaccine Clinical Guidance Working Group nakho kudonse ukunaka.
UCurtis uthe: “Kungakho abanye babo bephakamisa ukuthi, uma kungenzeka, isikhashana sokwelashwa kungase kube ukuhlakanipha.” “Lesi akusona isexwayiso esijwayelekile, lokhu kufanele ukwenze ngazo zonke izindlela, kodwa nge-rheumatism yakho Khuluma nodokotela ogulayo. I-ACR ithole izincomo zakamuva eqenjini elisebenzayo labaqondisi, futhi lezi zincomo zenziwe ezinsukwini ezimbalwa ezedlule. "
Ucwaningo olusha olushicilelwe ku-Gut luthole ukuthi iziguli ezinesifo samathumbu okuvuvukala ezithole i-infliximab zinempendulo encishisiwe yamasosha omzimba egomeni le-COVID-19 ngokushesha ngemuva komjovo wokuqala (Remicade, Janssen). Nokho, lapho isiguli esifanayo kamuva sithola umthamo wesibili wokwelashwa, ukusabela komzimba kwabonakala kuyinto evamile.
NgokukaCurtis, lokhu kunwebe isikhathi sokuthola umthamo wesibili ukuze wonge imithamo kwamanye amazwe, hhayi kuphela i-IBD ne-infliximab, kodwa nasezigulini ezinezifo eziningi ezizimele kanye nokwelashwa.
“Uma uhlala ezweni futhi i-US ingeyona enye yazo, lokhu kusho ukunweba isikhawu kusuka kudosi wokuqala kuye kweyesibili ukuze wonge umthamo ukuze wonke umuntu athole umthamo wokuqala. Ngicabanga ukuthi, Lokhu kungase kungabi umqondo omuhle kubantu abathola ukwelashwa kwe-immunomodulatory ye-Crohn's disease noma i-lupus, i-vasculitis, i-rheumatoid arthritis noma ezinye izifo." UCurtis. “Empeleni, akuyona nje i-infliximab, kodwa futhi ne-Remicade kanye [ne-biosimilars] i-Inflectra ne-Renflexis. Ngiyasola nokuthi izidakamizwa zethu eziningi ziyefana.”
Ubuye wengeza ukuthi manje sekunezifundo eziningi mayelana nokuphendula kweziguli ezinezifo ezizimele emgomeni we-COVID-19 ngemuva komthamo wokuqala nowesibili. Imiphumela ibonisa ukuthi amasosha omzimba aphelele azokhiqizwa kuphela ngemva kokuphela kochungechunge oluphelele lwemithi yokugoma. impendulo.
UCurtis uthe: "Manje, kunezifundo ezithile ezincwadini, bafunda ukuthi kwenzekani ngemuva kokuthatha umthamo wokuqala." Impendulo yokugoma yabantu abaningi ILUNGILE, kodwa kubantu abaningi, umphumela awumuhle kakhulu. Ngakho-ke, ngicabanga ukuthi ulwazi oluyinhloko engilufunde kweminye yemibhalo yesandla engiyibukezile isezindaweni zomphakathi, futhi eminye ithunyelwe kimi ngasese, futhi kufanele ngempela wamukele umthamo wesibili.
"Lokhu kuyiqiniso ikakhulukazi uma unesifo se-autoimmune noma uthola ukwelashwa okuthinta ukungatheleleki, ngoba ngaphandle kokuthi uqedele lonke uchungechunge lwezifundo njengoba bekulindelekile, abanye abantu bazoqhubeka nokuba sengozini futhi ngaphambi kokuthi kufinyelelwe impendulo elindelekile ye-antibody. umthamo wesibili.” Wengeza. “Khona-ke, ngokuvamile, iziguli ezine-rheumatism zibonakala zivikeleke kahle ngemva kokuthola umthamo wesibili, kodwa kukhona okuhlukile.”

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