Abemi abacinezelekileyo ngokwasemzimbeni "banokufuna" isitofu sokugonya se-COVID-19

I-webinar ye-Curtis J. Isigulana: isitofu sokugonya se-COVID-19 kunye nonyango. Somlomo: Isiseko soPhando lweRheumatism. Ngomhla we-11 kuCanzibe, ngo-2021 (I-Q&A eyi-Virtual).
I-webinar ye-Curtis J. Isigulana: isitofu sokugonya se-COVID-19 kunye nonyango. Somlomo: Isiseko soPhando lweRheumatism. Ngomhla we-11 kuCanzibe, ngo-2021 (I-Q&A eyi-Virtual).
UJeffrey R. Curtis, MD, usihlalo we-COVID-19 Vaccine Clinical Guidance Working Group ye-American Academy of Rheumatology, wathi abaguli abakhubazekileyo baya “kukwazi” ukusebenzisa rhoqo izitofu zokugonya ze-COVID-19 kwixesha elizayo.
UCurtis, ugqirha wamathambo, ugqirha wezifo zezifo, kunye nonjingalwazi kwezamayeza kwiYunivesithi yaseAlabama eBirmingham, uxelele abantu abebezimase umsitho wamva nje we-Q&A obubanjwe yiRheumatology Research Foundation ukuba ukholelwa ukuba isitofu sokugonya se-COVID-19 sinokuba yinto eqhelekileyo kwezi zigulana.
“Ewe, zininzi inzululwazi, kwaye inzululwazi ihlala iguquka. Nantoni na ocinga ukuba uyayazi kule nyanga, kwinyanga ezayo inokwahluka, ngenxa yesi sizathu, ndicinga ukuba yonke into esiyithethayo okanye esiyithethayo ngobu busuku inokutshintsha, ”utshilo uCurtis kubantu ababekho kwiforum yenyani. “Mna ngokwam ndicinga ukuba abantu banokufuna ii-boosters. Isenokungabi njalo kumntu wonke, kodwa ndicinga ukuba inokuba yinto eqhelekileyo ukufumana i-booster kwaye uyenze ngamaxesha athile. Inokuphela ngaphezulu okanye ngaphantsi njengesitofu sokugonya umkhuhlane, ukuba akunjalo minyaka le, emva koko uyawufuna minyaka le. ”
Wongeze ukuba ngokuxhomekeke kunyango isigulana esilufumanayo, abantu ngabanye banokuzuza ngakumbi kugonyo lwe-booster okanye uthotho oluphindaphindiweyo logonyo.
“Umntu othile kwincoko uphakamise imeko yokuba ingabiyiyo idosi okanye isitofu sokugonya abasifunayo, kuxhomekeke kunyango olufumanayo, le yinto yokuxoxa nomnikezeli wakho wezempilo,” utshilo uCurtis. "Kodwa ndicinga kakhulu ukuba umbono we-boosters unokuba nomtsalane."
Xa ebuzwa ngamathemba okusebenzisa i-Pfizer okanye uthotho lwesitofu sokugonya seModerna kunye nesixhasi senye inkampani, uCurtis waphendula wathi unethemba lokuba iingcali zingacebisa ukuba abantu baqhubeke nokusebenzisa olu gonyo njengesitofu sokuqala.
Uthe: “Kusenokwenzeka ukuba olu ayizukuba luphononongo olubanzi kwixesha elizayo.” “Ndizele lulindelo. Kufuneka ubambelele kwinkxaso onayo kwasekuqaleni.”
UCurtis uphinde waphawula ngamachiza athile e-rheumatic, kubandakanya i-rituximab (Rituxan, Genentech) kunye ne-mycophenolate mofetil, enokunciphisa ukusebenza kogonyo lwe-COVID-19.
Uthe: "Ndicinga ukuba iRituximab iya kuba lelinye lawona machiza anomdla." I-Rituximab iyasebenza kakhulu ekupheliseni iiseli ze-B kwaye yenza kube nzima ukuba umzimba uvelise izilwa-buhlungu. Oku kulungile xa unyanga into ene-antibodies ofuna ukuyisusa, kodwa ukuba ufuna ukunceda amajoni omzimba ukulwa nosulelo kwixesha elizayo, isenokungabi yinto entle. ”
I-Rituximab inokunciphisa impendulo ye-immune ukuya kwinqanaba elikhulu kunolunye unyango oluninzi. I-Mycophenolate mofetil yenye. "Ezi zizinto zimbini endinokuthandabuza kakhulu, ukuba ndiqiniseke ngokupheleleyo ukuba umntu ukhuselwe kakuhle kwi-COVID-19."
NgokukaCurtis, imiba ebandakanya i-JAK inhibitors kunye nokuncitshiswa kokuchaphazeleka kogonyo, kubandakanya ne-ACR COVID-19 Vaccine Vaccine Working Guidance Working Group nayo itsalele ingqalelo.
UCurtis wathi: “Kungenxa yoko le nto abanye babo becebisa ukuba, ukuba kunokwenzeka, ixesha elifutshane lonyango lisenokuba bubulumko.” “Esi ayisosilumkiso ngokubanzi, kufuneka wenze oku ngazo zonke iindleko, kodwa nge-rheumatism yakho Thetha nogqirha wesigulana. I-ACR ifumene iingcebiso zamva nje kwiqela elisebenzayo, kwaye ezi ngcebiso zenziwe kwezi ntsuku zimbalwa zidlulileyo. ”
Uphononongo olutsha olupapashwe kwi-Gut lufumanise ukuba abaguli abanesifo sokukrala kwamathumbu abafumana i-infliximab babenempendulo encitshisiweyo yokugonyela kugonyo lwe-COVID-19 ngoko nangoko emva kokutofa inaliti yokuqala (Remicade, Janssen). Nangona kunjalo, xa isigulane esifanayo kamva safumana umthamo wesibini wonyango, impendulo yokuzivikela komzimba ibonakala iqhelekileyo.
NgokukaCurtis, oku kwandise ixesha lokufumana idosi yesibini ukugcina iidosi kwamanye amazwe, kungekuphela nje kwi-IBD kunye ne-infliximab, kodwa nakwizigulana ezinezifo ezininzi ezizimelayo kunye nonyango.
Ukuba uhlala kwilizwe kwaye i-US ayikho enye yazo, ke oku kukwandisa ixesha ukusuka kwidosi yokuqala ukuya kwidosi yesibini ukugcina ithamo ukuze wonke umntu afumane idosi yokuqala. Ndicinga ukuba, oku akunakuba licebo elihle kubantu abafumana unyango lwe-immunomodulatory yesifo sikaCrohn okanye i-lupus, i-vasculitis, i-rheumatoid arthritis okanye ezinye izifo. UCurtis. “Enyanisweni, ayisiyo-infliximab kuphela, kodwa ikwa-Remicade kunye [ne-biosimilars] i-Inflectra kunye ne-Renflexis. Ndikwakrokrela ukuba uninzi lweziyobisi zethu ziyafana.”
Wongeze ukuba ngoku kukho izifundo ezininzi malunga nempendulo yezigulana ezinezifo ezizimelayo kugonyo lwe-COVID-19 emva kwedosi yokuqala neyesibini. Iziphumo zibonisa ukuba izilwa-buhlungu ezipheleleyo ziya kuveliswa kuphela emva kokuba uluhlu olupheleleyo lwezitofu zokugonya lugqityiwe. impendulo.
UCurtis uthe: "Ngoku, kukho izifundo kuncwadi, bafunda okwenzekayo emva kokuthatha idosi yokuqala." Impendulo yokugonywa kwabantu abaninzi ilungile, kodwa kubantu abaninzi, isiphumo asisihle kakhulu. Ngoko ke, ndicinga ukuba ulwazi oluphambili endilufundileyo kweminye yemibhalo-ngqangi endiyiphononongileyo ikwindawo yoluntu, kwaye ezinye zithunyelwe kum ngokufihlakeleyo, kwaye ngokwenene kufuneka wamkele idosi yesibini.
"Oku kuyinyani ngakumbi ukuba unesifo esizisebenzelayo okanye ufumana unyango oluchaphazela ukhuselo lomzimba, kuba ngaphandle kokuba ugqibe lonke uthotho lwezifundo njengoko bekulindelekile, abanye abantu baya kuqhubeka nokuba semngciphekweni kwaye ngaphambi kokuba impendulo ye-antibody elindelekileyo ifezekisiwe. ithamo lesibini.” Wongeza. Ke, xa sithetha ngokubanzi, abaguli abane-rheumatism babonakala bekhuselwe kakuhle emva kokufumana idosi yesibini, kodwa kukho izinto ezingafaniyo.

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