Immune yakadzvinyirirwa huwandu "vanga" vanoda COVID-19 vaccine booster

Curtis J. Patient webinar: COVID-19 yekudzivirira uye kurapwa. Mutauri: Rheumatism Research Foundation. Chivabvu 11, 2021 (Virtual Q&A).
Curtis J. Patient webinar: COVID-19 yekudzivirira uye kurapwa. Mutauri: Rheumatism Research Foundation. Chivabvu 11, 2021 (Virtual Q&A).
Jeffrey R. Curtis, MD, sachigaro weCCIDID-19 Vaccine Clinical Guidance Working Boka reAmerican Academy of Rheumatology, akataura kuti varwere vane immunosuppressed "zvichida" vanofanira kugara vachishandisa COVID-19 vaccine boosters mune ramangwana.
Curtis, rheumatologist, epidemiologist, uye purofesa wemishonga paYunivhesiti yeAlabama kuBirmingham, akaudza vaive pachiitiko cheQ&A chakaitwa neRheumatology Research Foundation kuti anotenda kuti COVID-19 vaccine booster inogona kuve yakajairika muvarwere ava.
“Chokwadi, kune sainzi yakawanda, uye sainzi iri kuramba ichishanduka-shanduka. Chero zvaunofunga kuti unoziva mwedzi uno, mwedzi unouya zvinogona kunge zvakasiyana, saka nechikonzero ichi, ndinofunga zvese zvatinotaura kana kutaura nezvazvo manheru ano Zvinogona kuchinja, ”Curtis akaudza vaive paforum. "Ini pachangu ndinofunga kuti vanhu vangangoda boosters. Zvinogona kunge zvisiri izvo kune wese munhu, asi ndinofunga zvingave zvakajairika kuwana booster uye wozozviita nguva nenguva. Inogona kupedzisira yawedzera kana kushoma senge yekudzivirira furuwenza, kana isiri gore rega rega, saka unoida kanenge gore rega rega.
Akawedzera kuti zvichienderana nemabatirwo anoitwa murwere, vanhu vanogonawo kuwana mukana wekubatsirwa nemajekiseni ebooster kana kudzokororwa majekiseni.
"Mumwe munhu munhaurirano akasimudza mamiriro ekuti angave asiri iwo dosi kana jekiseni ravaida, saka zvichienderana nekurapwa kwaunowana, ichi chinhu chekukurukura nemupi wehutano," Curtis akadaro. "Asi ini ndinofunga zvakanyanya kuti pfungwa yemabooster ingangove inoyevedza."
Paakabvunzwa nezve tarisiro yekushandisa Pfizer kana Moderna vaccine series neimwe kambani inosimudzira, Curtis akapindura kuti aitarisira kuti nyanzvi dzichakurudzira kuti vanhu varambe vachishandisa mushonga uyu semushonga wekutanga.
Iye akati: “Zvingangoitika kuti uku hakuzove ongororo yakazara munguva pfupi iri kutevera. “Ndizere netarisiro. Unofanira kuomerera kurutsigiro rwawakawana kubva pakutanga.”
Curtis akataurawo nezvemamwe madhiragi erheumatic, anosanganisira rituximab (Rituxan, Genentech) uye mycophenolate mofetil, inogona kuderedza kushanda kweCCIDID-19.
Iye akati: "Ini ndinofunga Rituximab ichave imwe yemishonga inofadza." Rituximab inoshanda zvakanyanya mukubvisa B masero uye kuita kuti zviome kuti muviri ugadzire masoja ekudzivirira chirwere. Ichi chinhu chakanaka kana iwe uchirapa chimwe chinhu chine masoja ekudzivirira chirwere chaunoda kubvisa, asi kana iwe uchida kubatsira immune system kurwisa hutachiona mune ramangwana, chingasava chinhu chakanaka. ”
Rituximab inogona kuderedza mhinduro yezvirwere zvemuviri kusvika pamwero mukuru kupfuura mamwe akawanda marapirwo. Mycophenolate mofetil imwe. "Izvi ndizvo zvinhu zviviri zvandingazeza zvakanyanya, kuve nechokwadi chekuti mumwe munhu akadzivirirwa kubva kuCOVID-19."
Sekureva kwaCurtis, nyaya dzinosanganisira JAK inhibitors uye yakaderedzwa maitiro ekudzivirira, kusanganisira iyo ACR COVID-19 Vaccine Clinical Guidance Working Boka zvakare yakwezva kutarisa.
Curtis akati: “Ndosaka vamwe vavo vachiti kana zvichiita, kurapwa kwenguva pfupi kungave kwakanaka. “Iyi haisi yambiro yakajairika, unofanira kuita izvi chero zvodii, asi nerheumatism yako Taura nachiremba murwere. ACR yakawana kurudziro yazvino kubva kuboka rinoshanda rekutungamira, uye kurudziro idzi dzakaitwa mukati memazuva mashoma apfuura. "
Chidzidzo chitsva chakaburitswa muGut chakawana kuti varwere vane chirwere chekuzvimba bowel vakagamuchira infliximab vaive neyakadzikiswa immune system kune yeCCIDID-19 vaccine mushure mekutanga jekiseni (Remicade, Janssen). Zvisinei, apo murwere mumwe chete akazogamuchira mushonga wechipiri wekurapa, mhinduro yekudzivirira zvirwere yakaita seyakajairika.
Sekureva kwaCurtis, izvi zvakawedzera nguva yekugamuchira yechipiri dosi kuchengetedza madosi mune dzimwe nyika, kwete chete yeBD uye infliximab, asiwo kune varwere vane dzakawanda autoimmune zvirwere uye marapiro.
"Kana iwe uchigara munyika uye US isiri imwe yadzo, saka izvi ndezvekuwedzera nguva kubva pamushonga wekutanga kusvika kune yechipiri dosi kuchengetedza dosi kuitira kuti munhu wese awane yekutanga dosi. Ndinofunga, Iri rinogona kunge risiri zano rakanaka kune vanhu vari kurapwa immunomodulatory chirwere cheCrohn's kana lupus, vasculitis, rheumatoid arthritis kana zvimwe zvirwere. Curtis. "Chaizvoizvo, haisi infliximab chete, asiwo Remicade uye [biosimilars] Inflectra uye Renflexis. Ndinofungidzirawo kuti mishonga yedu yakawanda yakafanana.”
Akawedzera kuti pari zvino pane zvidzidzo zvakati wandei pamusoro pemhinduro yevarwere vane autoimmune zvirwere kune COVID-19 yekudzivirira mushure mekutanga neyechipiri dosi. Mhedzisiro yacho inoratidza kuti masoja ekudzivirira chirwere akazara anozogadzirwa chete mushure mekunge nhevedzano yejekiseni yapera. mhinduro.
Curtis akati: "Zvino, pane zvidzidzo mumabhuku, vanodzidza zvinoitika mushure mekutora dosi rekutanga." Mhinduro yejekiseni yevanhu vazhinji yakanaka, asi kuvanhu vazhinji, mhedzisiro yacho haina kunyatsonaka. Nokudaro, ndinofunga kuti ruzivo rukuru rwandakadzidza kubva kune mamwe manyoro andakaongorora ari munharaunda yevanhu, uye mamwe akatumirwa kwandiri pachivande, uye iwe unofanira kubvuma chiyero chechipiri.
"Izvi ndezvechokwadi kunyanya kana uine chirwere che autoimmune kana kuti uri kuwana marapirwo anokanganisa kusadzivirirwa kwemuviri, nekuti kunze kwekunge wapedza nhevedzano yezvidzidzo sezvaitarisirwa, vamwe vanhu vacharamba vari panjodzi uye mhinduro inotarisirwa isati yaitwa, Vakawana. mushonga wechipiri.” Akawedzera. "Zvino, kazhinji kutaura, varwere vane rheumatism vanoita kunge vakachengetedzwa zvakanaka mushure mekugamuchira muyero wechipiri, asi pane zvimwe zvakasarudzika."

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